Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host−Virus Interaction, and Proposed Neurotropic Mechanisms
COVID19: Neurological involvement in COVID-19 We investigate the density of the expression levels of ACE2 in the CNS, the host−virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.
The Neuroinvasive Potential of SARS‐Cov2 May Be At Least Partially Responsible for the Respiratory Failure of COVID‐19 Patients
Coronaviruses are not always confined to the respiratory tract and that they may also invade the central nervous system inducing neurological diseases. The potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19. Awareness of this will have important guiding significance for the prevention and treatment of the SARS‐CoV‐2‐induced […]
Epileptic Activity In Neurological Deterioration After Ischemic Stroke, A Continuous EEG Study
STROKE: NCSE after stroke is common; EEG should be considered for prompt diagnosis and treatment
Intubation for Psychogenic Non-Epileptic Attacks: Frequency, Risk Factors, and Impact on Outcome
PNEA: Significant resources are utilized, and real harm may occur to patients with psychogenic non-epileptic attacks (PNEA) who are not diagnosed quickly and treated early
Nonconvulsive Status Epilepticus: Overlooked and Undertreated
EMERGENCY DEPT: Underutilization of EEG and underdiagnosis of NCSE in the emergency department
Meta-analysis and Cost-effectiveness of Second-line Antiepileptic Drugs for Status Epilepticus
HEALTH ECONOMICS: Ceribell leads to improved ROI and significant cost savings as a result of improved patient management
Role of Epileptic Activity in Older Adults With Delirium, a Prospective Continuous EEG Study
CONFUSION/DELIRIUM IN ELDERLY: NCSE is more common in elderly patients; EEG should be considered for elderly patients experiencing acute confusional state or delirium, even in the presence of a presumed symptomatic cause NCSE was found in 6 (12%) patients and interictal discharges in 15 (30%). There was no difference in the prevalence of epileptic activity […]
Altered Mental Status: Current Evidence-based Recommendations for Prehospital Care
EMERGENCY DEPT: Underutilization of EEG and underdiagnosis of NCSE in the emergency department
Cefepime-Induced Neurotoxicity: A Systematic Review
CAFEPIME: NCSE is common in patients who have been given Cefepime; EEG should be considered for those experiencing Altered Mental Status Cefepime-induced neurotoxicity is challenging to recognize in the critically ill due to widely varying symptoms that are common in ICU patients. This adverse reaction can occur despite appropriate dosing, usually resolves with drug interruption, […]
Prognostic Significance of Clinical Seizures After Cardiac Arrest And Target Temperature Management
CARDIAC ARREST: Seizures and NCSE are common in post-cardiac arrest patients and are correlated with poor outcomes; time to normal is correlated with good neurologic outcomes.
Continuous Amplitude-integrated Electroencephalographic Monitoring Is a Useful Prognostic Tool for Hypothermia-treated Cardiac Arrest Patients
CARDIAC ARREST: Seizures and NCSE are common in post-cardiac arrest patients and are correlated with poor outcomes; time to normal is correlated with good neurologic outcomes
Acute Brain Failure in Severe Sepsis: A Prospective Study in the Medical Intensive Care Unit Utilizing Continuous EEG Monitoring
SEPSIS: NCS and periodic discharge are common in septic patients; EEG may be considered for prompt diagnosis NCS and PD are common in patients with severe sepsis and altered mental status. Lack of EEG reactivity was more frequent in patients on continuous sedation and was associated with mortality up to 1 year after discharge.
